A loop‐shaped minimally invasive brush for improved cytology sampling of pancreatic cysts during EUS‐FNA

Pancreatic cancer is the fourth leading cause of cancer-related deaths in West and has a 5-year survival rate only 2%–9%. cystic lesions are precursors pancreatic cancers prime target for early diagnosis. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) enables collection fluid aiming diagnosis malign premalign cysts. However, this acellular or paucicellular 20% cases, hampering proper Here, we introduce minimally invasive Nitinol brush that can be operated through 413 µm lumen 22G FNA needle. During operation, rotated against inner wall cyst, removing cells dispersing them fluid, where they aspirated We demonstrate function using three models. An vitro cyst model was used to visualize brushing procedure mechanical interaction between spherical cavity. Ex vivo porcine intestine bovine ovary models were how increases number harvested with more than one order magnitude. These results indicate potential adenocarcinoma.